Senin, 24 November 2014

## Free Ebook Chapter 31, Inducible Pluripotent Stem Cells In Autism Spectrum Disorders, by Joseph Buxbaum

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NOTE: This is a single chapter excerpted from the book The Neuroscience of Autism Spectrum Disorders, made available for individual purchase. Additional chapters, as well as the entire book, may be purchased separately.


Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder.  New research is leading to greater understanding of and ability to treat the disorder at an earlier age.  It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention.

Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years.  With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models.  Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage.  Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise.



*Uniquely explores ASDs from a neurobiological angle, looking to uncover the molecular/cellular basis rather than to merely catalog the commonly used behavioral interventions
*Comprehensive coverage synthesizes widely dispersed research, serving as one-stop shopping for neurodevelopmental disorder researchers and autism specialists
*Edited work with chapters authored by leaders in the field around the globe - the broadest, most expert coverage available

  • Sales Rank: #3964410 in eBooks
  • Published on: 2012-10-25
  • Released on: 2012-10-25
  • Format: Kindle eBook

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Jumat, 21 November 2014

>> Free Ebook Chapter 37, Getting from 1,000 Genes to a Triad of Symptoms: The Emerging Role of Systems Biology in Autism Spectrum Disorders, by Joseph

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NOTE: This is a single chapter excerpted from the book The Neuroscience of Autism Spectrum Disorders, made available for individual purchase. Additional chapters, as well as the entire book, may be purchased separately.


Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder.  New research is leading to greater understanding of and ability to treat the disorder at an earlier age.  It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention.

Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years.  With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models.  Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage.  Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise.



*Uniquely explores ASDs from a neurobiological angle, looking to uncover the molecular/cellular basis rather than to merely catalog the commonly used behavioral interventions
*Comprehensive coverage synthesizes widely dispersed research, serving as one-stop shopping for neurodevelopmental disorder researchers and autism specialists
*Edited work with chapters authored by leaders in the field around the globe - the broadest, most expert coverage available

  • Published on: 2012-10-25
  • Released on: 2012-10-25
  • Format: Kindle eBook

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Kamis, 20 November 2014

~~ Free PDF Chapter 15, Emergency Medicine and Critical Care for Nonhuman Primates (American College of Laboratory Animal Medicine), by Christian Abee

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NOTE: This is a single chapter excerpted from the book Nonhuman Primates in Biomedical Research, made available for individual purchase. Additional chapters, as well as the entire book, may be purchased separately.


The second edition of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Biology and Management volume provides basic information on the natural biology of nonhuman primates and the current state of knowledge regarding captive management.Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject.



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  • Sales Rank: #3565680 in eBooks
  • Published on: 2012-03-29
  • Released on: 2012-03-29
  • Format: Kindle eBook

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0 of 0 people found the following review helpful.
Five Stars
By Vicki L Pulley
I live with a monkey so it is good information to have.

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Der vorliegende Band „Mamma, Weibliches Genitale, Schwangerschaft und Kindererkrankungen“ enthält eine systematische Darstellung der pathologischen Veränderungen der genannten Organe, Organsysteme und Erkrankungsgruppen. Dabei werden alle Erkrankungen, die sich in den verschiedenen, zum Teil miteinander funktionell verbundenen, zum Teil unabhängig voneinander existierenden Organen beobachten lassen, beschrieben.
Die Verfasser der verschiedenen Unterkapitel sind renommierte europäische Pathologen aus den verschiedenen Arbeitskreisen, die sich mit den o. g. Themen diagnostisch und wissenschaftlich intensiv beschäftigen. Dabei wird insbesondere auf die modernen Entwicklungen der verschiedenen Teilbereiche eingegangen und die neuen Veränderungen in Terminologie, Klassifikation und molekularen Analysen detailliert dargestellt. Dieses stets unter dem Blickwinkel der diagnostischen Pathologie.
Insgesamt ist das Ziel der vorliegenden Kapitel, Grundlage und Informationsquelle für die tägliche diagnostische Arbeit auf hohem Niveau zu sein.

  • Sales Rank: #3975278 in eBooks
  • Published on: 2012-11-02
  • Released on: 2012-11-02
  • Format: Kindle eBook

Review

Aus den Rezensionen:

 

“... Insgesamt ein sehr gut gelungenes und übersichtlich gegliedertes Nachschlagewerk mit zahlreichen Bildern, das die tägliche Routinediagnostik erleichtern sollte.“ (Dr. Martin Hyden, in: Kärntner Ärztezeitung, Heft 6, Juni 2014)

From the Back Cover

Der vorliegende Band „Mamma, Weibliches Genitale, Schwangerschaft und Kindererkrankungen“ enthält die pathologischen Veränderungen derselben. Dabei werden alle Erkrankungen, die sich in den verschiedenen, zum Teil miteinander funktionell verbundenen, zum Teil unabhängig voneinander existierenden Organen beobachten lassen, beschrieben.

Die Verfasser der verschiedenen Unterkapitel sind renommierte europäische Pathologen aus den verschiedenen Arbeitskreisen, die sich mit den o. g. Themen diagnostisch und wissenschaftlich intensiv beschäftigen. Dabei wird insbesondere auf die modernen Entwicklungen der verschiedenen Teilbereiche eingegangen und die neuen Veränderungen in Terminologie, Klassifikation und molekularen Analysen detailliert dargestellt. Dieses stets unter dem Blickwinkel der diagnostischen Pathologie.

Insgesamt ist das Ziel der vorliegenden Kapitel, Grundlage und Informationsquelle für die tägliche diagnostische Arbeit auf hohem Niveau zu sein.

About the Author

Manfred Dietel  erhielt nach dem Medizinstudium an der Universität Hamburg und seiner weiteren wissenschaftlichen Ausbildung am Institut für Pathologie des Universitäts-Krankenhauses Hamburg Eppendorf dort eine Professur für das Fach "Pathologie und Pathologische Anatomie" im Fachbereich Medizin der Universität Hamburg. Mit seiner Berufung zum ordentlichen Professor wurde er 1989 Direktor des Instituts für Allgemeine Pathologie der Christian-Albrechts-Universität zu Kiel und wechselte 1993 in seine jetzige Stellung als Direktor des Instituts für Pathologie der Charité, Rudolf-Virchow-Haus, Humboldt-Universität zu Berlin.

Er war und ist in der akademischen Selbstverwaltung u.a. tätig als Dekan der Medizinischen Fakultät der Charité der Humboldt-Universität, Mitglied des Wissenschaftlichen Beirats der Bundesärztekammer, Ärztlicher Direktor und Vorsitzender des Vorstandes der Charité und Mitglied des Medizinausschuss des Wissenschaftsrats. Aktuell ist Professor Dietel Vorsitzender des Vorstands der Deutschen Gesellschaft für Pathologie und Mitglied des Vorstands der Deutschen Gesellschaft für Senologie und der Deutschen Gesellschaft für Telemedizin.

Dietels wissenschaftliches Interesse gilt insbesondere der molekularen Tumorpathologie mit Untersuchungen zur Zytostatikaresistenz, prädiktiven Testung zum therapeutischen Ansprechen maligner Tumore und zu tumorassoziierten genetischen Veränderungen (mol. Biomarker). Weitere Schwerpunkte sind neue Verfahren in der histologischen Diagnostik maligner Tumoren (spez. Gynäkopathologie) und die technische Entwicklung von Telepathologiesystemen. Sein Fokus in Krankenversorgung und Lehre sind die histologische Diagnostik an operativ oder endoskopisch entnommenem Gewebsmaterial (in vivo-Diagnostik).

 

Günter Klöppel, Professor emeritus für Pathologie, Institut für Pathologie, Technische Universität München und Christian-Albrechts-Universität zu Kiel.

Günter Klöppel hat sich durch zahlreiche wichtige Beiträge auf dem Gebiet der Pankreaspathologie und der Pathologie der neuroendokrinen Tumoren ausgezeichnet. Diese entstanden zu einem großen Teil am Institut für Pathologie der Universität Kiel, das er nach seinem Wechsel von Brüssel nach Kiel über 13 Jahre leitete und zu einer führenden Institution machte. Nach seiner Emeritierung hat er seine wissenschaftlichen Tätigkeiten am Institut für Pathologie der Technischen Universität München fortgesetzt. Die wichtigsten wissenschaftlichen Beiträge erfolgten auf dem Gebiet der kindlichen Nesidioblastosen, der Vorläuferläsionen des Pankreaskarzinoms und ihrer molekularen Progression, der Beschreibung und Klassifizierung spezieller Pankreastumoren, der Pathogenese der alkoholischen und autoimmunen Pankreatitis und der Klassifikation gastroenteropankreatischer neuroendokriner Tumoren. Die molekulare Genese der neuroendokrinen Neoplasien des Duodenum und Pankreas bei MEN1 wurden von seinen Mitarbeitern und ihm erstmals auf Gewebsebene erforscht und eingehend charakterisiert. Aufbauend auf diesen Arbeiten wurde eine Hypothese zur schrittweisen molekularen Entstehung neuroendokriner Tumoren aus frühen und späten Stammzellen entwickelt.

Günter Klöppel hat zahlreiche wissenschaftliche Preise gewonnen und ist Mitglied der Deutschen Akademie der Wissenschaften Leopoldina.

 

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Pathologie: Mamma, Weibliches Genitale, Schwangerschaft und Kindererkrankungen (German Edition), by Wolfgang Remmele PDF
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Rabu, 19 November 2014

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Lots of insects suck blood, but one species above all others has a reputation for this, out of all proportion to its size: the mosquito. Due to the diseases they carry and inject, mosquitoes are responsible for more human deaths than any other animal. The most deadly of these diseases is malaria, which although eradicated from much of the northern hemisphere, continues to pose a mortal threat in developing countries. Two billion people a year are exposed to malarial infection, of which over 350 million succumb and nearly 700,000 die, the majority in sub-Saharan Africa.
In Mosquito, Richard Jones recounts the history of mosquitoes’ relationship with mankind, and their transformation from a trivial gnat into a serious disease-carrying menace. Drawing on scientific fact, historical evidence, and literary evocation, the book provides a colourful portrait of this tiny insect and the notorious diseases it carries.
Mosquito offers a compelling warning against the contemporary complacency surrounding malaria and other diseases in western society, whilst also exploring the sinister reputation of the insect in general. Written in an accessible style for a broad readership, the title will appeal to all those with an interest in tropical medicine and disease, as well as anyone pestered in the night by the annoying, familiar whine of this diminutive air-borne adversary.

  • Sales Rank: #1908662 in eBooks
  • Published on: 2013-02-26
  • Released on: 2013-02-26
  • Format: Kindle eBook

About the Author

Richard Jones is a fellow of the Royal Entomological Society of London and the Linnean Society of London and former president of the British Entomological and Natural History Society. His books include Nano Nature and Extreme Insects.

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0 of 0 people found the following review helpful.
About all you might want to know about mosquitos. Illustrations are superb.
By lyndonbrecht
This is another successful volume in a large series, one of the better ones. It is well-written and the illustrations are quite excellent. The illustrations with commentary could almost be another book. There's a quite striking mosquito mask (Kwakwaka'wakw, as the Northwest coast group is now known). There are several rather amazing posters from the World War 2 era. The book has eleven short chapters, which overlap a but. There's a lot of information. Once fascinating detail (I've read of this elsewhere) is that mosquitoes have infested the London Underground now for a century and appear to have evolved into a new species, with differences in behaviors and DNA; there even may be subspecies.

Much of the book is really about malaria (and also Yellow Fever), how the cause was discovered and methods for fighting the disease, which means fighting mosquitoes. This is a fascinating story, and includes how DDT was once considered a miracle. Malaria once was common in many places, with American history buffs knowing of the common ravages of malaria and yellow fever in places like New Orleans. The "ague" in Britain and other conditions were once common. The manner in which the diseases use mosquitoes as vectors in discussed in comprehensible terms. There's some natural history, although only a few of the 3,500+ species are described.

The chapter titled "The Theater of War" is the best in the book, describing the war against mosquitoes (including mosquito netting) but also malaria in time of war, specifically World War 2, when DDT was used with no awareness of impact, but it probably saved a huge number of lives.

0 of 0 people found the following review helpful.
Short, nicely written, nicely illustrated study
By Anson Cassel Mills
Jones' book is a fine contribution to the large Reaktion "Animal series": short, profusely illustrated volumes dedicated to individual animals. Although Jones is a fellow of the Royal Entomological Society of London, he also writes good layman's English. He succinctly describes the wonder of mosquito physiology, the growing realization that mosquitoes were vectors for serious diseases, the tactics used to reduce their numbers and treat the diseases, and the environmental crisis that ensued following the widespread spraying of DDT during the mid-20th century. Jones also dedicates a chapter to "The Mosquito Brand," the naming of ships, planes and the like for mosquitoes and the use of mosquitoes as symbols on postage stamps. It is sobering to realize that even in the 21st century, mosquitoes are "arguably the most dangerous animal in the world," responsible for more than a million deaths annually, many of them children.

A pair of American eyes might have smoothed over some unnecessary idiosyncrasies of (in George Bernard Shaw's words) the common language that separates us and prevented the relocation of Harvard to Washington, DC (104). I also think that readers with enough sophistication to read this book do not need to be told in such heavy-handed fashion that (for instance) it would no longer be politically correct for war propaganda to portray mosquitoes with stereotypical Japanese facial features.

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Senin, 17 November 2014

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Vascular care has evolved from conservative therapy and open surgical therapy to a minimally invasive approach using endovascular techniques, laparoscopic or thoracoscopic techniques as well as hybrids of open and endovascular techniques. This volume provides up-to-the-minute information and details new developments and procedures.

  • Sales Rank: #2423659 in eBooks
  • Published on: 2012-12-14
  • Released on: 2012-12-14
  • Format: Kindle eBook

Review

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"Vascular Surgery … is intended as a comprehensive detailed guide to performing vascular procedures. … supply a valuable resource for vascular surgeons of any level. … The chapters are well written and supply any surgeon with a valuable resource on how to perform a multiplicity of vascular operations. Overall … can be highly recommended. The vascular surgery atlas truly provides a step-by-step guide for surgeons undertaking vascular procedures and interventions. This text would be of particular use for vascular surgery trainees … ." (Todd R. Vogel, Journal of the American Medical Association, Vol. 302 (10), September, 2009)

"This well-written vascular surgery atlas presents a detailed practical guide for each procedure with excellent color diagrams. … Vascular surgeons of any level and general surgeons performing vascular procedures and interventions are the intended audience. … This is as an excellent and up-to-date vascular surgery atlas. … This book clearly has an advantage over other texts due to the comprehensive, high-quality illustrations, the outstanding contributors, and the recognized expertise of the editors." (Manuel Garcia-Toca, Doody’s Review Service, November, 2009)

From the Back Cover

Vascular care has evolved from conservative therapy and open surgical therapy to a minimally invasive approach using endovascular techniques, laparoscopic or thoracoscopic techniques as well as hybrids of open and endovascular techniques. New technological developments continue to arise allowing surgeons to be more creative and adding to the treatment options available. 

 

Vascular Surgery provides up-to-the-minute information and details new developments and procedures in the field of vascular surgery. With an authorship of international acclaim, this comprehensive text is a highly valuable resource for surgeons and trainees.

About the Author
Professor Jamal J. Hoballah -- Currently at the University of Iowa Hospitals and Clinics, Professor Hoballah has published numerous books with Springer and is a renowned and respected specialist in his field. Authored and co-edited books include: Vascular Reconstructions: Anatomy, Exposures, and Techniques; Operative Dictations in General and Vascular Surgery. He has published extensively both in books and in journals, and is a member of (amongst others) the Peripheral Vascular Surgical Society, the Society for Clinical Vascular Surgery, the Society of Critical Care Medicine, and the International Union of Angiology. He has been president of the Johnson County Medical Society (President 2002-2003) and the Iowa Vascular Surgery Society (President 2002-2004.) His university fellowships include both New York University Medical Center and the University of Iowa. In the last couple of years, Jamal Hoballah has won the accolade of one of the Best Doctors in America (2004; 2006).

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NOTE: This is a single chapter excerpted from the book Epigenetics in Human Disease, made available for individual purchase. Additional chapters, as well as the entire book, may be purchased separately.


Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike.



  • Comprehensive coverage of fundamental and emergent science and clinical usage
  • Side-by-side coverage of the basis of epigenetic diseases and their treatments
  • Evaluation of recent epigenetic clinical breakthroughs

  • Published on: 2012-07-26
  • Released on: 2012-07-26
  • Format: Kindle eBook

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